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SC 1-21:  Multiplatform National Approach for Providing Guidance on Integrating Basic Science and Epidemiological Studies on Low-Dose Radiation Biological and Health Effects

Committee members

Scientific Committee 1-21 will prepare a commentary on critical research needs for evaluation of low-dose radiation biological and health effects. The focus of the commentary will be on the integration of results of basic science studies, including biomarkers of cancer and other diseases, with epidemiological studies on health effects of low-dose radiation exposures.

In September and October 2012, the Co-Chairs, Staff Consultant, and NCRP President held planning teleconferences with webinar support to map out the next steps. The first Committee meeting was held on November 12, 2012. The Committee discussed perspectives on integrating basic biology and epidemiology and developed an initial outline for the report. Committee members volunteered for writing assignments best suited to their expertise.

The Committee met August 12–13, 2013 in Bethesda, Maryland to review the material collected to date. A revised outline and general timeline for the commentary was developed. The working title is “Health Effects of Low Doses of Radiation: Integrating Basic Science and Epidemiology,” and the overall working outline is:

  • Introduction
  • Description of Basic Radiobiology and Recent Advances
  • Description of Existing Epidemiologic Studies
  • General Approaches to Risk Assessment
  • Integration of Biology and Epidemiology
  • Closing the Gaps Towards an Integrated Approach

A complied first draft is expected to be distributed to the Committee members by mid-December 2013, and the next meeting is scheduled for January 28–29, 2014.

NCRP is grateful to the Centers for Disease Control and Prevention and the U.S. Department of Energy for financial support for this work.

The membership of SC 1-21 is:

S.A. Amundson , Co-Chair
J.L. Bernstein, Co-Chair
K.F. Eckerman
R.A. Guilmette
A. Kronenberg
M.P. Little
W.F. Morgan
J.A. Nickoloff
S.N. Powell
D.O. Stram
R.J. Preston, Consultant
M. Rosenstein, Staff Consultant


November 12-13, 2012 >

SC 1-20 Biological Effectiveness of Low Linear-Energy Transfer
Radiation as a Function of Energy >

SC 1-22 Radiation Protection for Astronauts in Short-Term Missions >

SC 1-23 Guidance on Radiation Dose Limits for the Lens of the Eye >

SC 1-24 Radiation Exposures in Space and the Potential for Central Nervous System Effects >

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